What is PDE5 inhibitors They represent a major first-line oral therapy option for men with ED. The prevalence and health implications of ED are far-reaching. Based on the impending shift in the oral PDE5 inhibitor market from brand to generic products, patients and providers will have more freedom of choice, and cost will be a lesser consideration. Although multiple reports suggest general equivalency of efficacy and safety between the four major PDE5 inhibitors, tadalafil with optimal use has been suggested to be preferable, providing increased efficacy in the ability to insert and the successful completion of intercourse. AEs, onset and duration of action, administration considerations, precautions, and cost are all key factors in individualizing therapy. Choice of oral PDE5 inhibitor therapy should be guided by a discussion between patient and provider that focuses on understanding the various characteristics, which can increase the likelihood of satisfaction.
What is PDE5 inhibitors
The currently available PDE5 inhibitors, including the more recently approved avanafil, provide men with ED with a safe, convenient, and effective method for improving erectile function. These agents have become the first-line therapy for ED and are preferred by health care practitioners and patients because of their ease of use, quick onset of action, and tolerability. Given the lack of adequate head-to-head trials, it is difficult to determine the superiority of one agent over another. Further studies comparing these agents are needed to distinguish the possible benefits of each, particularly in specific subsets of patients.
All PDE5 inhibitors allow for flexibility in prescribing and patient preference based on individual response and need. Specific characteristics of each agent (cost, ease of use, and adverse effects) should be used to guide appropriate treatment.
What is PDE5 inhibitors?
Various PDE5 inhibitor drugs are available, and people will usually take them in tablet form.
In the United States, the following PDE5 inhibitors are available:
- avanafil (Stendra), to treat erectile dysfunction
- vardenafil (Levitra), for the treatment of erectile dysfunction
- tadalafil (Cialis, Adcirca), for the treatment of erectile dysfunction and pulmonary hypertension
- sildenafil (Viagra, Revatio), to treat erectile dysfunction and pulmonary hypertension
Other PDE5 inhibitors includeTrusted Source:
- phentolamine (Regitine)
- yohimbine (Yocon)
- L-arginine
